![]() Two studies were publicly funded and in one of these studies, the lead author was a consultant for several pharmaceutical companies and also received investigator-driven funding from two companies, however none of these companies manufacture bupropion. Four studies were funded by industry, but the impact of this on study results is unknown. Four studies explicitly excluded participants with psychiatric comorbidity and one study included only participants with opioid dependency. Study intervention length varied from six to 10 weeks. ![]() All studies evaluated a long-acting version of bupropion, with the dosage ranging from 150 mg up to 450 mg daily. Five studies were conducted in the USA, and one in Iran. We included six studies with a total of 438 participants. Further studies are needed, to assess whether bupropion is effective in specific ADHD subgroups or in people who have additional disorders. Also, no studies assessed the long-term effects of this drug. The effect of bupropion on various aspects of daily functioning was not investigated. The quality of the evidence in this review is low, because we found very few studies five of the six studies were small, and all were poorly conducted. Bupropion may be an alternative treatment for adults with ADHD who cannot or will not take stimulant drugs. The drug does not have more adverse effects than treatment with placebo. In one of the publicly-funded studies, the lead author was paid by industry (although not by the manufacturers of buproprion) for research activities.īupropion may lead to a small improvement in ADHD and it may also decrease symptoms related to ADHD. In one study, all participants had ADHD and were addicted to opioids (a drug that relieves pain).įour studies were funded by industry and two studies were publicly funded. All participants were diagnosed with ADHD, and often had other mental health problems. The duration of the studies varied between six and 10 weeks. This simple dosage suits people with ADHD, as the illness may make it difficult for them to remember to take their medication. All evaluated a long-acting version of bupropion, that is to say, a version of the drug is absorbed slowly, and can therefore be taken just once a day. The studies included 438 people with ADHD. Five of the studies took place in the USA, and the sixth in Iran. We included six randomised controlled trials (RCTs), that is, studies in which participants are randomly allocated to one of two or more treatment groups. The evidence is current to February 2017. Its effectiveness in treating ADHD is not yet known. Nonstimulants such as bupropion are therefore sometimes used instead. Other people may not want to use stimulants, as these are controlled substances. Others have medical conditions such as psychiatric conditions or tic disorders that make it not possible to use stimulants. Some people cannot tolerate stimulants because of side effects. However, not everyone responds well to stimulants. People with ADHD are usually prescribed stimulant drugs such as methylphenidate and amphetamines. Bupropion is a drug that is registered for the treatment of depression and for stopping smoking, but is also used to treat ADHD. ![]() Some people with ADHD only have problems with one of the behaviors, while others have a combination. We also reviewed adverse effects (side effects experienced as a result of taking the drug).ĪDHD is a brain disorder marked by an ongoing pattern of inattention, impulsivity and/or excessive activity, which interferes with functioning or development. We reviewed the evidence on the effects of the drug bupropion in adults with ADHD.
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